John C. Lyne, M.D.

Education

1982	University of Waterloo Waterloo, Ontario, Canada	BSc
1984	University of Waterloo Waterloo, Ontario, Canada	MSc
1989	University College Dublin Dublin 4, Ireland	M.D.

Professional Experience

Intern/Junior Resident PGY1-2 7/89 to 6/91	Western Pennsylvania Hospital Pittsburgh, PA	General Surgery
Resident PGY3-7 7/91 to 6/96	University of Pittsburgh Medical Center Pittsburgh, PA	General/Urologic Surgery
Staff Fellow PGY8-9 7/96 to 6/98	National Cancer Institute Bethesda, MD	Urologic Oncology
Attending 6/98 to 5/03 Dep't of Surgery	Allegheny General Hospital, Pittsburgh PA UPMC Passavant, Pittsburgh, PA Suburban General Hospital, Pittsburgh, PA

Additional Professional Activites

House Physician 3/93 to 1/98

St. Clair Memorial Hospital 1000 Bower Hill Road Pittsburgh, PA

House Physician 4/96 to 3/98

UPMC/South Side Hospital 9th and Mary Streets Pittsburgh, PA

Emergency Room Physician 4/96 to 1/98

Wetzel County Hospital New Martinsville, WV

House Physician 7/97 to 6/98

Suburban Hospital 9800 Old Georgetown Road Bethesda, MD

Medical Licensure
Pennsylvania: MD349283L

Board Certification
Board Certification 2-2000. Diplomate #12299

Awards and Distinctions

1983	University of Waterloo Graduate Scholarship University of Waterloo, Ontario, Canada
1986, 1987, 1988	First In Class - 2nd, 3rd and 4th medical years University College Dublin
1989	Winner - Consultants Prize in Medicine and Surgery St. Vincents Hospital, Dublin, Ireland
1989	Second Place - Gold Medal in Surgery St. Vincents Hospital, Dublin, Ireland
4/93	Best Research Paper Pittsburgh Urologic Association, Residents Day
4/94	Best Research Paper Pittsburgh Urologic Association, Residents Day
9/94	Third Place - Residents Essay Award North East Section , American Urological Association Lake George, NY
4/95	Best Research Paper Pittsburgh Urologic Association, Residents Day
4/96	Best Research Paper Pittsburgh Urologic Association, Residents Day
1996-1998	American Foundation of Urologic Disease Scholar (AFUD) National Cancer Institute, National Institutes of Health Bethesda, MD

Abstracts/Presentations
Lyne JC, Goldfarb I, Slater H: The Management of Electrical Burn Injuries American Burn Association, Baltimore, MD, 5/91.

Lyne JC, Bellinger MF: Early Experience with Transurethral Electrical Bladder Stimulation. Pittsburgh Urologic Residents Day, 4/92. Bellinger MF, Lyne JC: Early Experience with Transurethral Electrical Bladder Stimulation. American Academy of Pediatrics, Washington, DC, 5/92.

Lyne JC, Jordan ML: Cadaveric Renal Transplantation against a Positive Historical Crossmatch under FK506 Immunosuppression. Pittsburgh Urologic Residents Day, 4/93.

Lyne JC: The Expression of Neu Differentiation Factor (NDF) and HER2/Neu by Human Prostate Cancer Cells. Pittsburgh Urologic Residents Day, 4/94.

Lyne JC, Jordan ML, Vivas CA, Shapiro R, Scantlebury VP, Hakala TR, Starzl TE: Cadaveric Renal Transplantation Against a Positive Historical Crossmatch under FK506 Immunosuppression. AUA, San Francisco, CA, 5/94.

Lyne JC, Jordan ML, Vivas CA, Shapiro R, Scantlebury VP, Hakala TR, Starzl TE: Cadaveric Renal Transplantation Against a Positive Historical Crossmatch under Tacrolimus Immunosuppression. AUA, North East Section, Lake George, NY, 9/94.

Lyne JC, Deng D. Finley G, Salup RR: Human Prostate Cancer Cells Respond to but do not Secrete NDF of HER2/Neu Gene Amplification and Protein Overexpression. ACCR, Toronto, Canada, 3/95.

Lyne JC and Salup RR: The Biologic Effect of Neu Differentiation Factor on Human Prostate Cancer Cells. Pittsburgh Urologic Residents Day, 4/95.

Lyne JC, Melhem M, Finley G, Salup RR: The Expression of NDF/Heregulin and its Receptors HER2, HER3 and HER4 in Normal and Cancerous Prostate Tissue. Pittsburgh Urologic Residents Day, 4/96.

Salup RR, Melhem M, Deng D, Liu N, Lyne JC: Expression of NDF/Heregulin and its Receptors in Human Prostate Tissue and Cancer. AACR, Washington, DC, 4/96.

Lyne JC, Melhem M, Deng D, Finley G, Liu N, Salup RR: The Expression of NDF/Heregulin and its Receptors HER2, HER3 and HER4 in Normal and Cancerous Prostate Tissue. AUA, Orlando, FL, 1996.

Lyne JC, Glenn GM, Humphrey JS, Choyke PL, Enquist EG, Hurley KM, Manolatos CG, Stolle CA, Zhuang Z, Oldfield EH, Walther MM, Zbar B, Klausner RD, Linehan WM: Loss on One Allele of the VHL Tumor Suppressor Gene: Phenotypic Assessment. AUA, (#561), 1998.

Lyne JC, Glenn GM, Choyke PL, Libutti SK, Rayford W, Humphrey J, Hurley KM, Manolatos CT, Oldfield E, Walther MM, Klausner RD, Zbar B, Linehan WM: A Review of the Prevalence, Age of Onset and Association of the Manifestations of VHL Disease in Patients Screened at a Single Institute. AUA, (#639), 1998.

Cohen JK, Miller RJ, Rooker GM, Lyne JC: Cancer control following cryosurgical ablation of the prostate when used as primary treatment for clinically localized prostate cancer. J Urol 163:A, 2000.

Publications
Lyne JC, Bellinger MF: Early Experience with Transurethral Electrical Bladder Stimulation. J Urol 150(2pt2):697-698, 1993.

Lyne JC, Flood HD: Bilateral Fungal Epididymo-Orchitis with Abscess. Urology 46(3):412-414, September 1995.

Lyne JC and Bellinger MF: Management of the Adolescent Varicocele. Pediatric Urology, 1995. Edited by: J.S. Elder, New York, Igaku-Shoin Medical Publishers, Inc.

Konety BR, Singh J, Lyne JC, Salup RR: Leiomyosarcoma with Osteoclast Like Giant Cells of the Spermatic Cord. A Case Report and Review of the Literature. Urol Int 46(3):259-262, September 1996.

Lyne JC, Melhem MF, Finley GG, Wen D, Liu N, Deng DH, Salup RR: Tissue Expression of Neu Differentiation Factor/Heregulin and its Receptor Complex in Prostate Cancer and its Biologic Effects on Prostate Cancer Cells In Vitro. Cancer J Sci Am 3(1):21-30, January-February 1997.

Lyne JC and Bahnson RR: The Surgical Management of Invasive Urothelial Cancer. Urologic Cancer, 1997. Edited by: MS. Ernstoff, JA Heaney and RE Peschel, New York, WW Norton and Company.

Lyne JC, Vivas CA, Shapiro R, Scantlebury V, Hakala TR, Starzl TE, Jordan ML: Cadaveric Renal Transplantation Against a Positive Historical Crossmatch under Tacrolimus Immunosuppression: Long-term Followup. Transplant Proc 29(12):312, February-March, 1997.

Choyke PL, Walther MM, Wagner JR, Rayford W, Lyne JC, Linehan WM: Renal Cancer: Preoperative Evaluation with Dual-Phase Three Dimensional MR Angiography. Radiology 205(3):767-771, December 1997.

Walther MM, Libutti SK, Lyne JC, Rosenberg SA, Linehan WM: Laparoscopic Cytoreductive Nephrectomy as Preparation for Administration of Systemic Interleukin-2 in the Treatment of Metastatic Renal Cell Carcinoma: A Pilot Study. Urology 53(3):496-501, 1999

Walther MM, Choyke PL, Glenn GM, Lyne JC, Rayford W, Linehan WM: Renal Cancers in VHL: Prospective Analysis of a 3 cm Tumor size Threshold for Renal Parenchymal Sparing Surgery. J Urol 161(5):1475-1479, 1999

Cole KA, Chuaqui RF, Katz K, Pack S, Zhuang Z, Lyne JC, Linehan WM, Liotta LA, Emmert-Buck MR: cDNA sequencing and analysis of POV1 (PB39): a novel gene up- regulated in prostate cancer. Genomics 51(2):282-287, 1998.

Walther MM, Keiser HR, Choyke PL, Rayford W, Lyne JC, Linehan WM: Management of hereditary pheochromocytoma in von Hippel-Lindau kindreds with partial adrenalectomy. J Urol 161(2):395-398, 1999.

Lyne JC, Medicare Reform And Your Practice: What You Need To Know. Urology, Volume 64, Number 5A: Pages 2 to 7, Supplement to November 2004.

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