David A. Corral, M.D., F.A.C.S.

Education

B.A., Biochemistry	Canisius College, Buffalo, NY 1981-1985
M.D.	SUNY Health Science Center, Syracuse, NY 1985-1989 Academic Research Track
Resident	Univ. Pittsburgh Medical Center, Pittsburgh, PA 1989-1995 Urologic Surgery
Fellow	University of Texas, M. D. Anderson Cancer Center, Houston, TX 1995-1998 Urologic Surgery

Employment History

2001-Present	Triangle Urological Group
1998-2001	Assistant Professor, Department of Urologic Oncology Department of Surgical Oncology Adjunct Member Department of Molecular and Cellular Biophysics Roswell Park Cancer Institute Division of Urologic Oncology
1998-2001	Assistant Professor, Department of Urology State University of New York at Buffalo
2003-present	Assistant Professor, Department of Surgery Drexel University College of Medicine

Professional Memberships and Activities
Specialty Board Certification
American Board of Urology, March 14, 2000 Number 1815

National Boards
National Board of Medical Examiners, July 1, 1990 Number 369366

State Licensure
Pennsylvania: Number MD045294L
New York: Number 209568

National Societies
American Urological Association (National and Northeastern Section)
American Association of Clinical Urologists
New York Academy of Science
The Society of Surgical Oncology
The Society of Urological Oncology
Fellow of the American College of Surgeons

National/Regional Committees
Scientific Program Director - The Northeastern Section of the American Urological Association 56th Annual Meeting, Savannah, GA, 10/28-31/2004.
Pennsylvania Representative to the American Urological Association - October, 2005 - September 2007.

University Service

1998-1999	Course Coordinator, RPCI Urological Oncology Didactic Conference
1998-2001	Instructor, University at Buffalo Medical School Physical Diagnosis Course
Oct-Dec, 1998	Residency Interviewer, State University of New York at Buffalo, Department of Urology
Oct-Dec, 1999	Residency Interviewer, State University of New York at Buffalo, Department of Urology
2000-2001	Member, Election and Bylaws Committee of the Faculty Council of the School of Medicine and Biomedical Sciences
2000-2001	Member, Doctoral Thesis Review Committee: Candidate- Kristin Kee, Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute
2000-2001	Member, Doctoral Thesis Review Committee: Candidate- David Schuster, Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute

Hospital Service

1999-2001	Member, Surgical Quality Improvement Case Review Committee
1999-2001	Member, Medical Records Committee
1999-2001	Member, Scientific Review Committee
1999-2001	Member, Continuing Medical Education Advisory Committee
2000-2001	Member, Pharmacy and Therapeutics Committee
2000-2001	Chairman, Operating Room Committee
2002-present	Member, Executive Committee of the Allegheny Cancer Center

Editorial Boards

1999-2001

Editor-In-Chief, Cancer Research Alert American Health Consultants Atlanta, Georgia

Awards and Honors

2000	The Pfizer Scholars in Urology Award
1996-1997	University Cancer Foundation Clinical Oncology Fellowship (University of Texas M. D. Anderson Cancer Center, Houston, Texas)
1996-1997	Clinical Oncology Fellowship; American Cancer Society, Texas Division
1995-1996	Clinical Oncology Fellowship (ACS COF#95-190-1); American Cancer Society

Teaching Activities
College/High School Students

Medical Students
Lecturer, University at Buffalo
Second Year Medical Student Physical Diagnosis Course
Veterans Administration Medical Center - 12/02/98, 12/13/99

Lecturer, University at Buffalo
Surgical Oncology for the Generalist Physician
Third Year Medical Students
Roswell Park Cancer Institute - 02/19/99, 03/19/99, 2/1/00

Moderator, University at Buffalo
Case Conference Presentations: Surgery 700
Third Year Medical Students
Roswell Park Cancer Institute - 9/23/99, 3/16/00,11/30/00

Laboratory Students/Fellows/Post-Docs
Mentor, David Schuster, Doctoral Graduate Student
Department of Molecular and Cellular Biophysics, RPCI - 7/99 - present

Lecturer, RPCI Urological Oncology Didactic Conference
Molecular Biology for the Urologist - 5/24/99, 5/15/00

Urology Residents
Lecturer, Urology Resident Didactic Teaching Session
Mechanisms of Cancer Invasion and Metastasis
Erie County Medical Center - 03/10/99

Moderator, Urology Resident Didactic Teaching Session
Erie County Medical Center - 11/11/98, 2/24/99, 5/12/99, 11/10/99

Course Faculty Appointments
Faculty, Preparatory Course for Urology Certifying Exam — Part II (Mock OralBoards) Phoenix, AZ — 1/2003, 2004, 2005, 2006

Moderator, Allegheny Cancer Center Symposium: Frontiers in the Multidisciplinary Management of Common Malignancies; Prostate Cancer Section, Pittsburgh, PA 7/30-31/2004

Grant Support

Title:	Novel Approaches to Gene Therapy and Chemotherapy in Highly Malignant Androgen-Independent Prostate Cancer Cells
Source:	Roswell Park Alliance Grant
Role:	C0-Principal Investigator (15%)
Amount:	$25,000
Date:	2001-2002

Title:	Photodynamic Therapy using 2-[1-hydroxyethyl]-2-devinylpyropheophorbide-a (HPPH) for Recurrent Bladder Cancer
Source:	Colby Bladder Cancer Research Grant/Roswell Park Alliance Foundation
Role:	Principal Investigator (15%)
Amount:	$47,060
Date:	2000-2001

Title:	Regulation of Apoptosis in Parental and Highly Metastatic Variant Prostate Cancer Cells Lines by Human Calcium-independent Phospholipase A2
Source:	Roswell Park Alliance Grant
Role:	Principal Investigator (15%)
Amount:	$30,000
Date:	1999-2000

Title:	Magnetic Resonance Imaging of Pulmonary Metastases of Renal Cell Carcinoma
Source:	Cuvelier Grant for Renal Cell Carcinoma Research
Role:	Principal Investigator (10%)
Amount:	$10,000
Date:	1998

Title:	Specific Reversible Osteoblast Ablation in Transgenic Mice
Source:	University Cancer Foundation Clinical Oncology Fellowship	(University of Texas M. D. Anderson Cancer Center, Houston, Texas)
Role:	Principal Investigator (100%)
Amount:	$54,000
Date:	1996-1997

Title:	Osteoblast Gene Expression in Osteoblast/Prostate Cancer Cell Coculture
Source:	American Cancer Society, Texas Division
Role:	Principal Investigator (100%)
Amount:	$3,600
Date:	1996-1997

Title:	Isolation and Characterization of Novel Prostatic Factors That Regulate Osteoblast Gene Expression.
Source:	American Cancer Society Clinical Oncology Fellows Research Funds Grant (ACS COF#95-190-1);
Role:	Principal Investigator (100%)
Amount:	$10,000
Date:	1995-1996

Title:	Influence of Prostatic Factors on Osteoblast Gene Expression.
Source:	University of Texas M. D. Anderson Cancer Center Physician Referral Service
Role:	Principal Investigator (100%)
Amount:	$4,000
Date:	1995-1996

Publications: Peer-reviewed
Tempel, G.E., Cook, J., Wise, W., Halushka, P., Corral, D.A.: Improvement in Organ Blood Flow by Inhibition of Thromboxane Synthetase During Experimental Endotoxic Shock in the Rat. J Cardiovascular Pharmacology, 8:514-9, 1986.

Chu, T.M., Kawinski, E., Hibi, N., Croghan, G., Wiley, J., Killian, C.S., Corral, D.A.: Prostate-Specific Antigenic Domain of Human Prostate Specific Antigen Identified with monoclonal Antibodies. J Urol 141:152-6, 1989.

Killian, C.S., Corral, D.A., Kawinski, E., Constantine, R.I.: Mitogenic Response of Osteoblast Cells to Prostate Specific Antigen Suggests an Activation of Latent TGF-Beta and a Proteolytic Modulation of Cell Adhesion Receptors. Biochem Biophys Res Comm 192(2):940-7, 1993.

Corral, D.A., Darras, F.S., Jensen, C.W., Hakala, T.R., Krause, J.R., Naides, S.J., Starzl, T.E., Jordan, M.L.: Parvovirus B19 Infection Causing Pure Red Cell Aplasia in a Renal Transplant Recipient of Pediatric Donor Kidneys. Transplantation 55(2):427-30, 1993.

Corral, D.A., Bahnson, R.R.: Recurrent Transitional Cell Carcinoma in an Ileal Conduit Treated by Sandwich Chemotherapy and Surgical Resection. J Urol 150:471-2, 1993.

Corral, D.A., Bahnson, R.R.: Treatment of Pathologic Stage T3N+MO Bladder Cancer: The Case for Observation. Seminars in Urology, Vol. XI, No 2:64-68, May, 1993.

Corral, D.A., Bahnson, R.R.: Survival of Men with Clinically Localized Prostate Cancer Detected in the Eighth Decade of Life. J Urol 151:1326-9, 1994.

Konety, B.R., Xerogeanes, J., Corral, D.A., Gruen, G., Hrebinko, R.: Ureteral Entrapment in the Sacroiliac Joint in Pelvic Trauma. Journal of Trauma 40:150-1, 1996.

Corral, D.A., Pisters, L.L., vonEschenbach, A.C.: Treatment Options for Localized Recurrence of Prostate Cancer Following Radiation Therapy. Urologic Clinics of No Amer 23(4):677-84, 1996.

Corral, D.A., Dinney, C.P.N.: Radical Cystectomy: Posterior Dissection Following Prior Therapy. J Surg Onc 64:165-6, 1997.

Corral, D.A., Logothetis, C.J.: New Approaches in the Treatment of Metastatic Transitional Cell Cancer of the Bladder. World J Urol 15:139-143, 1997.

Geoffroy, V., Corral, D.A., Zhou, L., Lee, B., Karsenty, G.: Genomic Organization of the Human CBFA1 Gene, and Evidence for an Alternative Splicing Event Affecting Protein Function. Mammalian Genome 9:54-7, 1998.

Corral, D.A., Sella, A., Pettaway, C.A., Amato, R.J., Jones, D.M., Ellerhorst, J.: Combination Chemotherapy for Metastatic or Locally Advanced Genitourinary Squamous Cell Carcinoma: A Phase II Study of Methotrexate, Cisplatin and Bleomycin (MBP). J Urol 160:1170-4, 1998.

Corral, D.A., Amling, M., Premiel, M., Loyer, E., Fuchs, F., Ducy, P., Baron, R., Karsenty, G.: Dissociation Between Bone Resorption and Bone Formation in Osteopenic Transgenic Mice. Proceedings of the National Academy of Sciences 95: 13835-40, 1998.

Corral, D.A., Cleary, K.R., Pisters, L.L.: Renal Cell Carcinoma Drop Metastasis to the Left Spermatic Vein in a Patient with Prior Varicocele Ligation. J Pelvic Surg, 6:42-43.

Corral, D.A., Varma, D.G., Jackson, E.F., Amato, R.J., Donat, S.M., Pisters, L.L.: Magnetic Resonance Imaging and Magnetic Resonance Angiography Prior to Postchemotherapy Retroperitoneal Lymph Node Dissection. Urology, 55:262-266, 2000.

Corral, D.A., Rodriguez-Bigas, M.A., Intengan, M.: Local Invasion of Prostate Carcinoma Causing Vesicorectal Fistula. J Urol, 164:1662-1663, 2000.

Wu, D., Gibbs, J., Corral, D.A., Intengan, M., Brooks, J.J.: Massive Localized Lymphedema: Additional Locations and Association with Hypothyroidism. Human Pathology, 31:1162-1168, 2000.

Publications: Invited and non-peer reviewed
*Denotes fellows, residents and medical students
Corral, D.A.: Converting a normal cell to a cancer cell: A new tool, a new insight. Cancer Research Alert 1:49-51, 1999.

Kang, H.J.* and Corral, D.A.: Telomerase activity in prostatic and renal cell carcinoma. Cancer Research Alert 1:54-56, 1999.

Corral, D.A.: The NIH peer review process:Your input is requested for an impending overhaul. Cancer Research Alert 1:58-59, 1999.

Vontagma, R.* and Corral, D.A.: Secondary malignancies induced by radiation exposure: Clinical examples and current experimental findings. Cancer Research Alert 1:61-64, 1999.

Lewis, R.D.* and Corral, D.A.: Cyclooxygenase-2 and colorectal cancer. Cancer Research Alert 1:67-69, 1999.

Corral, D.A.: What are contract research organizations and why are they on my TV? Cancer Research Alert 1:71-72, 1999.

Corral, D.A.: A self-replicating RNA vaccine: More than just increased copy number. Cancer Research Alert 1:109-111, 2000.

Polsky, S.M* and Corral, D.A.: Slow acetylation of N-acetyltransferase 2 and the risk of bladder cancer. Cancer Research Alert 1:117-120, 2000.

Corral, D.A.: Polyamines and polyamine regulators in prostate cancer. Cancer Research Alert 1:128-129, 2000.

Book Chapters
Corral, D.A., Bahnson, R.R.: Tumor Markers in Genitourinary Cancer - Urologic Cancer, ed. M.S. Ernstoff, J.A. Heany and R.E. Reschel. Cambridge, MA: Blackwell Science, Inc., Chap. 47, pp. 668-685, 1997.

Corral, D.A., Pettaway, C.A.: Cancer of the Penis and Urethra - Surgical Oncology: Contemporary Principles and Practice, ed. K.I. Bland, J.M. Daly and C.P. Karakousis: Stanford, CT: Appleton and Lange, 2000 (in press).

Internet Educational Activities
Corral, D.A.: Current Therapy for Clinically Localized Prostate Cancer. Sponsors: PDR.Net (Medical Economics, Inc., Montvale, NJ) and Cancerfacts.com (http://oncology.pdr.net/oncology/index.htm), May 16, 2000.

Abstracts: National/International Presentation with Referenced Publication

Abstracts: National/International Meeting Presentations/Publications in Meeting Proceedings
Corral, D.A., Killian, C.S., Kawinski, E., Constantine, R., Huben, R.P., Chu, T.M.: Osteoblast Mitogenic Activity in Benign Prostatic Hyperplasia, Primary and Metastatic Prostatic Cancer. J Urol 139:50 (Abstr # 107), 1988.

Killian, C.S., Corral, D.A., Kawinski, E., Constantine, R.I.: Activation of Latent Transforming Growth Factor-? by Proteolytic Activity of Prostate Specific Antigen. Abstract American Assoc Clin Chem, 1992.

Salup, R.R., Corral, D.A., Sicker, D., Wolmark, N.: Peptide-induced Augmentation of Renal Cancer Cells to Lysis by Natural Killer and Cytotoxic Lymphocytes. American Assoc Canc Res 35:492 (Abst # 2930), 1994.

Corral, D.A., Sicker, D.C., Salup, R.R.: Stimulation of Osteoblasts by Growth Factors from Human Prostate Cancer Cell Line Supernatants. American Assoc Canc Res 35:279 (Abstr # 1669), 1994.

Corral, D.A., Sikes, R.A., Karsenty, G.: Absence of Regulation of in vitro Osteoblast-specific gene Expression by Two Prostate Cancer Cell Lines. 7th Prouts Neck Meeting on Prostate Cancer Biology and Treatment, 1996.

Corral, D.A., Wood, C.G., Pettaway, C.A., Liebert, M.: Calbindin D-28K Expression by Prostate Cancer Cells is Upregulated by Differentiation Agents and Decreased in Highly Metastatic Variants of a Model of Progression. J Urol 157 Supp 4 (Abstr # 14), 1997.

Corral, D.A., Amling, M.A., Premiel, M., Barron, R., Karsenty, G.: Reversible Targeted Ablation of Osteoblasts in Transgenic Mice: An Animal Model of Osteoporosis. Am Soc Bone & Min Res Ann Mtg, 1997.

Varma, D.G.K., Jackson, E.F., Corral, D.A., Pisters, L.L.: MRI Imaging and MR Angiography Prior to Postchemotherapy Retroperitoneal Lymphadenectomy for Nonseminomatous Germ Cell Testicular Cancer. Intern Soc for Mag Reson in Medicine, 6th Scientific Mtg, 1998.

Pisters, L.L., Corral, D.A., Varma, D.G.K., Jackson, E.F., Amato, R.J., Donat, S.M.: Magnetic Resonance Imaging and Magnetic Resonance Angiography Prior to Post-chemotherapy Retroperitoneal Lymph Node Dissection. J Urol 159 Supp 5 (Abstr # 182), 1998.

Corral, D.A., Slaton, J.W., Perrotte, P., Dinney, C.P.N., Grossman, H.B.: Examination Under Anesthesia (EUA) in the Staging and Management of Bladder Cancer in the Contemporary Era. J Urol 239 Supp 5 (Abstr # 819), 1998.

Corral, D.A., Sella, A., Pettaway, C.A., Amato, R.J., Logothetis, C.J., Ellerhorst, J.: Combination Chemotherapy for Metastatic or Locally Advanced Genitourinary Squamous Cell Carcinoma: A Phase II Study of Methotrexate, Cisplatin and Bleomycin (MPB). J Urol 159 Supp 5 (Abstr # 626), 1998.

Nicotera, T.M., Klaich, G., Spehar, G., Corral, D.A.: Apoptosis of Human Prostate Cancer PC-3 Cells via Inhibition of Cytosolic Phospholipase A2. Proceeding of the Am Assoc Can Res 40:166 (Abstr # 1103), 1999.

Nicotera, T.M., Schuster, D, P., Nemi, R. Klaich, G. and Corral, D, A.: Loss of expression of alternate splice forms of Ca++-independent phospholipase A2 in highly malignant prostate cancer cell lines. Proceeding of the Am Assoc Can Res 41:48 (Abstr #303 ), 2000.

Corral, D.A., Schuster, D.P., Nemi, R., Klaich, G. and Nicotera, T.M.: Alternative splice variants of Ca++-independent phospholipase A2 in highly malignant prostate cancer cells. Proceedings of the Northeast Section of the American Urological Association 52 (Abstr #17), 2000.

Polsky, Stewart M. and Corral, D.A.: Sarcomatoid renal cell carcinoma: Ten year retrospective review at Roswell Park Cancer Institute. Proceedings of the Northeast Section of the American Urological Association 52 (Abstr #40), 2000.

Presentations: National and International
Corral, D.A., Killian, C.S., Kawinski, E., Constantine, R., Huben, R.P., Chu, T.M.: Osteoblast Mitogenic Activity in Benign Prostatic Hyperplasia, Primary and Metastatic Prostatic Cancer. J Urol 139:50 (Abstr # 107), 1988.

Corral, D.A., Sicker, D.C., Salup, R.R.: Stimulation of Osteoblasts by Growth Factors from Human Prostate Cancer Cell Line Supernatants. American Assoc Canc Res 35:279 (Abstr # 1669), 1994.

Corral, D.A., Sikes, R.A., Karsenty, G.: Absence of Regulation of in vitro Osteoblast-specific gene Expression by Two Prostate Cancer Cell Lines. 7th Prouts Neck Meeting on Prostate Cancer Biology and Treatment, 1996.

Corral, D.A., Wood, C.G., Pettaway, C.A., Liebert, M.: Calbindin D-28K Expression by Prostate Cancer Cells is Upregulated by Differentiation Agents and Decreased in Highly Metastatic Variants of a Model of Progression. J Urol 157 Supp 4 (Abstr # 14), 1997.

Corral, D.A., Amling, M.A., Premiel, M., Barron, R., Karsenty, G.: Reversible Targeted Ablation of Osteoblasts in Transgenic Mice: An Animal Model of Osteoporosis. Am Soc Bone & Min Res Ann Mtg, 1997.

Varma, D.G.K., Jackson, E.F., Corral, D.A., Pisters, L.L.: MRI Imaging and MR Angiography Prior to Postchemotherapy Retroperitoneal Lymphadenectomy for Nonseminomatous Germ Cell Testicular Cancer. Intern Soc for Mag Reson in Medicine, 6th Scientific Mtg, 1998.

Pisters, L.L., Corral, D.A., Varma, D.G.K., Jackson, E.F., Amato, R.J., Donat, S.M.: Magnetic Resonance Imaging and Magnetic Resonance Angiography Prior to Post-chemotherapy Retroperitoneal Lymph Node Dissection. J Urol 159 Supp 5 (Abstr # 182), 1998.

Corral, D.A., Slaton, J.W., Perrotte, P., Dinney, C.P.N., Grossman, H.B.: Examination Under Anesthesia (EUA) in the Staging and Management of Bladder Cancer in the Contemporary Era. J Urol 239 Supp 5 (Abstr # 819), 1998.

Corral, D.A., Sella, A., Pettaway, C.A., Amato, R.J., Logothetis, C.J., Ellerhorst, J.: Combination Chemotherapy for Metastatic or Locally Advanced Genitourinary Squamous Cell Carcinoma: A Phase II Study of Methotrexate, Cisplatin and Bleomycin (MPB). J Urol 159 Supp 5 (Abstr # 626), 1998.

Presentations: Local and Regional
Department of Molecular and Cellular Biophysics
Roswell Park Cancer Institute
Osteoporosis in Transgenic Mice - 10/19/98

University at Buffalo Department of Dermatology Grand Rounds
Diagnosis and Management of Penile Cancer
University of Buffalo - 05/02/99

New Millennium Research Rounds in Therapeutics
Roswell Park Cancer Institute
Osteoblast Ablation in Transgenic Mice- 09/29/99

Prostate Cancer Research Group Retreat
Roswell Park Cancer Institute
Prostate Cancer: A Clinical Overview - 6/26/99

Surgery Attending Physician Laboratory Review
Roswell Park Cancer Institute
iPLA2 Splice Variants in Highly Metastatic Prostate Cancer Cells - 3/9/00

Urology Nursing 2000
Continent Cutaneous and Orthotopic Urinary Diversions
Adam's Mark Hotel, Buffalo, NY - 9/21/00

Grand Rounds Presentation
Urinary Retention and Incontinence: A Management Update
Allegheny General Hospital
Pittsburgh, PA - 2/19/02

Grand Rounds Presentation
Renal Cell Carcinoma: A Management Update
Indiana Hospital
Indiana, PA - 3/5/02

Grand Rounds Presentation
Erectile Dysfunction: A Management Update
Forbes Regional Hospital
Pittsburgh, PA - 4/10/02

Grand Rounds Presentation
Erectile Dysfunction: A Management Update
Somerset Hospital
Somerset, PA - 6/5/02

Speaker: South Hills and Western Branch
Allegheny County Medical Society Meeting
Renal Cell Carcinoma: A Management Update
Kirwan Heights, PA - 2/11/03

Grand Rounds Presentation
Renal Cell Carcinoma: A Management Update
Allegheny General Hospital
Pittsburgh, PA - 5/15/03

Grand Rounds Presentation
Current Management of Erectile Dysfunction in the Diabetic Patient
The Medical Center at Beaver
Beaver, PA - 11/14/03

Faculty Lecturer
Fifth Annual Controversies in Urology
Advanced Prostate Cancer - Hormone Ablation and Bone Preservation - 2/8/04
Alternative Medicine in Prostate Cancer Management - 2/9/04
Captiva Island, Fl -2/6/04 to 2/10/04

Faculty Lecturer
Indiana Urological Association Spring Meeting 2005
Prostate Cryosurgery: Past and Present
Indianapolis, IN - 5/7/05

Grand Rounds Presentation
Renal Cell Carcinoma: A Management Update
Allegheny General Hospital
Pittsburgh, PA - 2/21/06

Community Service
Volunteer Medical Consultant
US Too Prostate Cancer Support Group - 2000-present

Lecturer, US Too Prostate Cancer Support Group
New Therapies for Localized Prostate Cancer
Veterans Administration Medical Center - 03/02/99

Lecturer, Chattauqua Cancer Lecture Series
Prostate Cancer: Where We've Been, Where We're Going
Chattauqua Institute - 07/14/99

Lecturer, US Too Prostate Cancer Support Group
Advanced Prostate Cancer: Current Treatment and New Horizons
Veterans Administration Medical Center - 08/01/00

Lecturer, Allegheny Prostate Cancer Symposium
Detection and Treatment of Prostate Cancer Recurrence
Allegheny General Hospital - 09/19/01.

Lecturer, US Too Prostate Cancer Support Group
Advanced Prostate Cancer: Current Treatment and New Horizons
Medical Center at Beaver- 03/05/03

Lecturer, US Too Prostate Cancer Support Group
Advanced Prostate Cancer: Hormone Ablation and Bone Preservation
Allegheny General Hospital - 03/15/01.

Lecturer, US Too Prostate Cancer Support Group
Management of Urinary Obstruction in Prostate Cancer Patients.
Allegheny General Hospital - 08/16/01.

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